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Home / Biochemicals / Small Molecules

VUF 10166

SKU : BHB21300366

A Potent Antagonist of 5-Hydroxytryptamine Receptor 3A and 3B, and an Antagonist of H4 Histamine Receptor

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Mfr.No.	V-115, V-115_10 mg, V-115_25 mg, V-115_5 mg, V-115_50 mg
Description	VUF 10166 (#V-115) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C13H15Cl2N4.
Background	VUF 10166 is a potent and selective antagonist of 5-HT3A and B receptors. It binds specifically and with high affinity to 5-HT3A (IC50 ~ 0.04 nM) and blocks the serotonin binding site. There's evidence of lower affinity to 5-HT3A/B receptors due to the influence of an additional allosteric binding site in the heteromer2.VUF 10166 is able to bind to an orthosteric binding site of HT3A and 5-HT3A/B receptors - A+A? and an A+B? interface. binding to the A+B? interface in the 5-HT3A/B receptor may decrease the affinity of ligands binding to the A+A? site by allosterically increasing the rate of ligand dissociation from the adjacent orthosteric site1,3.The 5-HT3 receptor subtype is a member of the Cys-loop ligand-gated cation channels which are expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions4.Competitive antagonists of 5-HT3 receptors are used to treat symptoms of emesis arising from chemotherapy treatment and postoperative emesis after anesthesia and surgery. There is also a limited use of antagonists for treating irritable bowel syndrome2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.05 nM - 100 nM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	155584-74-0
Molecular Weight	262.74
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-Hydroxytryptamine Receptor 3A and 3B
Source	Synthetic
Activity	VUF 10166 is a potent and selective 5-HT3A and B receptor antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Thompson, A.J. et al. (2014) Neuropharmacology 86, 378. Thompson, A.J. et al. (2012) J. Pharmacol. Exp. Ther. 341, 350. Thompson, A.J. et al. (2013) ChemMedChem 8, 946. Kato, S. et al. (2013) Biol. Pharm. Bull. 36, 1406. Thompson, A.J. et al. (2012) J. Pharmacol. Exp. Ther. 341, 350.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300366-1	V-115_10 mg	10 mg	$85		Add to Cart
BHB21300366-2	V-115_25 mg	25 mg	$168		Add to Cart
BHB21300366-3	V-115_5 mg	5 mg	$66		Add to Cart
BHB21300366-4	V-115_50 mg	50 mg	$323		Add to Cart

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