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Home / Biochemicals / Small Molecules

Wortmannin

SKU : BHB21300375

A Selective, Potent Inhibitor of PI3-Kinase

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Mfr.No.	W-400, W-400_1 mg, W-400_5 mg
Description	Wortmannin (#W-400) is a highly pure, natural, and biologically active compound.
Molecular Formula	C23H24O8.
Synonyms	Natural
Background	PI 3 Kinase is an enzyme implicated in growth factor signal transduction by associating with receptor and non-receptory tyrosine kinases. Wortmannin, a fungal metabolite (Penicillium fumiculosum), is a potent and specific inhibitor of phosphatidylinositol 3-kinase (PI-3K).1 It is highly cell-permeable, binds to the catalytic subunit of PI-3K and inhibits the enzyme activity in vitro and in vivo.2,3In purified preparations and cell-free cytosolic fractions it is active at 5 nM. In fibroblasts Wortmannin abolishes PDGF-mediated Inositol(3,4,5) P3 formation (IC50 = 5 nM).4 In guinea pig neutrophils it inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50 nM), and also phospholipase D activation.5,6 In PC12 cells treated with NGF, Wortmannin blocks the elongation of neurites.7 In rat basophilic leukemia (RBL-2H3) cells it inhibits IgE mediated histamine secretion.8 At higher concentrations Wortmanin inhibits other kinases such as myosin light chain kinase (IC50 = 200 nM)9 and MAP kinase activation (IC50 = 200-300 nM) induced by platelet activating factor.10
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	20-100 nM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	19545-26-7
Molecular Weight	428.4
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	Wortmannin is a potent and specific inhibitor of PI3-kinase1. In PC12 cells treated with NGF, Wortmannin blocks the elongation of neurites2. At higher concentrations Wortmanin inhibits other kinases3,4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1S,6br,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(metho xymethyl)-9a,11b-dimethyl-3Hfuro(4,3,2-de)indeno(4,5,- h)-2-h)-2-benzopyran-3,6,9-trione.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Powis, G. et al. (1994) Cancer Res. 54, 2419. Ui, M. et al. (1995) Trends Biochem. Sci. 20, 303. Hazeki, O. et al. (1996) J. Lipid Mediat. Cell Signal. 14, 259. Wymann, M. et al. (1994) Biochem. J. 298, 517. Bonser, R.W. et al. (1991) Br. J. Pharmacol. 103, 1237 Arcaro, A. et al. (1993) Biochem. J. 296, 297. Kimura, K. et al. (1994) J. Biol. Chem. 269, 18961. Yano, H. et al. (1993) J. Biol. Chem. 268, 25846. Nakanishi, S. et al. (1992) J. Biol. Chem. 267, 2157. Ferby, I.M. et al. (1994) J. Biol. Chem. 269, 30485. Powis, G. et al. (1994) Cancer Res. 54, 2419. Kimura, K. et al. (1994) J. Biol. Chem. 269, 18961. Nakanishi, S. et al. (1992) J. Biol. Chem. 267, 2157. Ferby, I.M. et al. (1994) J. Biol. Chem. 269, 30485.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300375-1	W-400_1 mg	1 mg	$75		Add to Cart
BHB21300375-2	W-400_5 mg	5 mg	$243		Add to Cart
BHB21300375-3	W-400_5 mg	5x5 mg	$954		Add to Cart

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