TGF/SMAD Signaling Pathway SBE Report Cell Line-HEK293

Mfr.No.	ABC-RC122D
Description	The SBE Reporter &ndash; HEK293 Cell Line is designed for monitoring the activity of the TGF /SMAD signaling pathway. The transforming growth factor beta (TGF) signaling pathway is involved in a diverse range of cell processes such as differentiation, cell cycle arrest, and immune regulation. TGF signaling has been linked to cardiac disease, cancer, Alzheimer&rsquo;s and other human diseases. TGF proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to phosphorylation and activation of SMAD2 and SMAD3, which then form a complex with SMAD4. The SMAD complex then translocates to the nucleus and binds to the SMAD binding element (SBE) in the nucleus, leading to transcription and expression of TGF / SMAD responsive genes.
Categories	Transfected Stable Cell Lines
Application	For research use only
Host Cell	HEK293 cells
Species	Human

Shipping	Dry Ice
Storage	Liquid Nitrogen

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