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Home / Cells / Cell Lines

Woodchuck PD-L1 / TCR activator - CHO Recombinant Cell line

SKU : BHC18200190

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BPS Bioscience

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Mfr.No.	79457
Description	Recombinant CHO-K1 cells constitutively expressing woodchuck (groundhog, Marmota monax) PD-L1 (Programmed Cell Death 1 Ligand 1, CD274, B7 homolog 1 (B7- H1), GenBank accession # HQ403651) and an engineered T cell receptor (TCR) activator. Mycoplasma testing: The cell line has been screened using the PCR-based VenorGeM Mycoplasma Detection kit (Sigma-Aldrich, #MP0025) to confirm the absence of Mycoplasma species. Host Species: hamster Supplied as Each vial contains ~2.5 x 10^6 cells in 1 ml of 10% DMSO.
Background	The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes.
Application	Screen for activators or inhibitors of PD-1 signaling in a cellular context Screen PD-L1 antibodies for binding affinity Characterize the biological activity of PD-1 interactions with PD-L1
Host Cell	CHO
Synonyms	Groundhog, Marmota Monax, PD-L1, Programmed Cell Death 1 Ligand 1, CD274, B7 Homolog 1, B7-H1, TCR
Shipping Temperature	-80°C (dry ice)
Note	License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of Biohippo products to your laboratory. Biohippo does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact [email protected] for details. Publications using this cell line should reference Biohippo Inc. Warning: Avoid freeze/thaw cycles.

Storage Stability	Immediately upon receipt, store vials in liquid nitrogen.

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHC18200190	79457	2 vials	$10340		Add to Cart

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