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Home / Biochemicals / Small Molecules

Coenzyme A, Free Acid

SKU : BHB21200001

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Mfr.No.	A-02, A-02-10MG, A-02-25MG, A-02-50MG, A-02-100MG
Description	Coenzyme A (CoA) is a universal metabolic cofactor synthesized from cysteine, pantothenate, and ATP. It is notable for its role in the synthesis and oxidation of fatty acids and the oxidation of pyruvate in the citric acid cycle (Leonardi et al., 2005). All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate (Sibon & Strauss, 2016). Applications Coenzyme A (CoA) Free Acid is widely used in biochemical research and drug development due to its role as a cofactor in numerous enzymatic reactions, particularly in acyl group transfer processes. It is extensively applied in studies of metabolic pathways, such as the citric acid cycle and fatty acid metabolism, to explore enzyme functions, regulatory mechanisms, and potential therapeutic targets (Leonardi et al., 2005). CoA Free Acid is also valuable in drug discovery for evaluating inhibitors or activators of CoA-dependent enzymes, which are crucial for developing treatments for metabolic disorders and infections (Spry et al., 2008).
Appearance	White to slight yellow
Molecular Formula	C21H36N7O16P3S
Synonyms	Coenzyme A, CoA, CoA-SH, Aluzime, Coalip, Thiol-CoA
Shipping	Ambient temperature (styrofoam + ice gels)
Smiles	SCCNC(CCNC(C(C(C)(COP(O)(OP(O)(OCC(C(C1O)OP(O)(O)=O)OC1N(C2=NC=N3)C=NC2=C3N)=O)=O)C)O)=O)=O
Cas Number	85-61-0
Molecular Weight	767.53 g/mol
Solubility	Soluble in water
Origin	Biosynthetic
Lead Time	In Stock
Notes	Research Use Only

Purity	≥ 95.0%
Form	Lyophilized powder
Storage	-20°C in a cool and dry place
Stability	≥ 2 years
Packaging	PP screw vials

Product Manual	Technical Specification MSDS

Reference	1. Leonardi, R., Zhang, Y. M., Rock, C. O., & Jackowski, S. (2005). Coenzyme A: Back in action. Progress in Lipid Research, 44(2-3), 125-153. 2. Sibon, O. C. M., & Strauss, E. (2016). Coenzyme A: To make it or uptake it? Nature Reviews Molecular Cell Biology, 17(10), 606-607. 3. Spry, C., Kirk, K., & Saliba, K. J. (2008). Coenzyme A biosynthesis: An antimicrobial drug target. FEMS Microbiology Reviews, 32(1), 56-106.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21200001-1	A-02-10MG	10mg	$79.55		Add to Cart
BHB21200001-2	A-02-25MG	25mg	$81.25		Add to Cart
BHB21200001-3	A-02-50MG	50mg	$113.64		Add to Cart
BHB21200001-4	A-02-100MG	100mg	$161.93		Add to Cart

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