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Home / Biochemicals / Small Molecules

Cyclothiazide

SKU : BHB21300080

A Positive Allosteric Modulator of AMPA Receptors

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Alomone Labs

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Mfr.No.	C-205, C-205_10 mg, C-205_100 mg, C-205_25 mg, C-205_50 mg
Description	Cyclothiazide (#C-205) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C14H16ClN3O4S2.
Background	Cyclothiazide (CTZ) is one of the most potent benzothiadiazides, a class of positive allosteric modulators of non-NMDA-type glutamate receptors, that inhibit receptor desensitization with a marked selectivity for the flip splice variants of AMPA receptors. Specifically, CTZ is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. By using patch-clamp techniques, the effects of CTZ were studied in HEK 293 cells stably transfected with the rat flip GluR1 subunit. The AMPA currents were greatly potentiated by CTZ in a dose-dependent manner. For instance, pretreatment of the cells with 100 uM CTZ increased the peak AMPA current 90-fold (EC50 = 28 uM), the current at the end of AMPA application 636-fold (EC50 = 46 uM), and the current integrals 730-fold (EC50 = 41 uM)1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	2259-96-3
Molecular Weight	389.9
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	AMPA receptors
Source	Synthetic
Activity	Cyclothiazide is a selective AMPA receptor agonist (allosteric potentiator)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6-Chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2-4-benzothiadiazine-7-sulfonamide 1,1-dioxide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Avoid exposure to light. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Fucile, S. et al. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 2943. Johansen, T.H. et al. (1995) Mol. Pharmacol. 48, 946.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300080-1	C-205_10 mg	10 mg	$50		Add to Cart
BHB21300080-2	C-205_100 mg	100 mg	$323		Add to Cart
BHB21300080-3	C-205_25 mg	25 mg	$100		Add to Cart
BHB21300080-4	C-205_50 mg	50 mg	$180		Add to Cart

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