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Home / Assay Kits / ELISA Kits

ELISA Kit for Mouse Interferon-induced, double-stranded RNA-activated protein kinase

SKU : BHE13803306

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1135m
Antigen	EIF2AK2
Alternative Names	Eukaryotic translation initiation factor 2-alpha kinase 2 ; eIF-2A protein kinase 2 ; Interferon-inducible RNA-dependent protein kinase ; P1/eIF-2A protein kinase ; Protein kinase RNA-activated ; PKR ; Serine/threonine-protein kinase TIK ; Tyrosine-protein kinase EIF2AK2 ; 2.7.10.2 ; p68 kinase ; Pkr ; Prkr ; Tik
Categories	Elisa
Function	Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.
Specificity	Natural and recombinant Mouse Interferon-induced, double-stranded RNA-activated protein kinase
Detection Range	0.312-20ng/mL
Entryname	E2AK2_MOUSE
Method Type	Sandwich
Platform	PF00035
Protein Name	Interferon-induced, double-stranded RNA-activated protein kinase
Sensitivity	0.157ng/mL
Sequence	50: MASDTPGFYM ; DKLNKYRQMH ; GVAITYKELS ; TSGPPHDRRF ; TFQVLIDEKE ; 100: FPEAKGRSKQ ; EARNAAAKLA ; VDILDNENKV ; DCHTSASEQG ; LFVGNYIGLV ; 150: NSFAQKKKLS ; VNYEQCEPNS ; ELPQRFICKC ; KIGQTMYGTG ; SGVTKQEAKQ ; 200: LAAKEAYQKL ; LKSPPKTAGT ; SSSVVTSTFS ; GFSSSSSMTS ; NGVSQSAPGS ; 250: FSSENVFTNG ; LGENKRKSGV ; KVSPDDVQRN ; KYTLDARFNS ; DFEDIEEIGL ; 300: GGFGQVFKAK ; HRIDGKRYAI ; KRVKYNTEKA ; EHEVQALAEL ; NHVNIVQYHS ; 350: CWEGVDYDPE ; HSMSDTSRYK ; TRCLFIQMEF ; CDKGTLEQWM ; RNRNQSKVDK ; 400: ALILDLYEQI ; VTGVEYIHSK ; GLIHRDLKPG ; NIFLVDERHI ; KIGDFGLATA ; 450: LENDGKSRTR ; RTGTLQYMSP ; EQLFLKHYGK ; EVDIFALGLI ; LAELLHTCFT ; 500: ESEKIKFFES ; LRKGDFSNDI ; FDNKEKSLLK ; KLLSEKPKDR ; PETSEILKTL ; 515: AEWRNISEKK ; KRNTC
Sequence Length	515
String	Q03963
Sub Unit	Homodimer. Interacts with DNAJC3 and STRBP (By similarity). Forms a complex with FANCA, FANCC, FANCG and HSP70.

Uniprot	Q03963
Gene Name	Eif2ak2
Immunogen Species	Mus musculus (Mouse)
Kegg	mmu:19106
Unigene	Mm.378990

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SKU	Supplier No.	Size	Your price	Quantity
BHE13803306	E1135m	96T	$776		Add to Cart

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