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Home / Proteins & Peptide

ENA-78/CXCL5, Human(HEK 293-expressed)

SKU : BHP18500398

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iXCells Biotechnologies

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Mfr.No.	IX03255, IX03255-25, IX03255-5
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Description	Epithelial-derived neutrophil-activating peptide 78 (ENA-78) is a small cytokine belonging to the CXC chemokine family. It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of ENA-78 has also been observed in eosinophils, and can be inhibited with the type II interferon,IFN-gamma. ENA-78 stimulates the chemotaxis of neutrophils possessing angiogenic properties. It plays a role in reducing sensitivity to sunburn pain in some subjects, and could be a potential target used to understand more about pain in other inflammatory conditions. ENA-78 is well known to have chemotactic and activating functions on neutrophils, mainly during acute inflammatory responses. It can signal through the CXCR2 receptor.Recombinant ENA-78/CXCL5 produced in 293 cells is a single polypeptide chain containing 78 amino acids. rhENA-78/CXCL5 has a molecular mass of 8.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Formulation	Lyophilized after extensive dialysis against PBS.
Molecular Weight	8.5 kDa, observed by reducing SDS-PAGE.
Source	HEK 293
Host	Human
Accession Number	P42830
Endotoxin Level	0.2 EU/ug, determined by LAL method.
Notes	For research use only
Bioactivity	The EC50 value of human ENA-78/CXCL5 on Ca2+ mobilization assay in CHO-K1/ Galpha15/hCXCR2 cells (human Galpha15 and human CXCR2 stably expressed in CHO-K1 cells) is less than 200 ng/ml.

Synonyms	Small inducible cytokine B5, CXCL5, Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, ENA-78(1-78), chemokine (C-X-C motif) ligand 5, SCYB5.
Sequence	AGPAAAVLRE LRCVCLQTTQ GVHPKMISNL QVFAIGPQCSKVEVVASLKN GKEICLDPEA PFLKKVIQKI LDGGNKEN

Purity	98% as analyzed by SDS-PAGE.
Storage	Lyophilized recombinant human ENA-78/CXCL5 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human ENA-78/CXCL5 should be stable up to 1 week at 4°C or up to 2 months at -20°C.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP18500398-1	IX03255-25	25ug	$120		Add to Cart
BHP18500398-2	IX03255-5	5ug	$49		Add to Cart

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