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Home / Biochemicals / Small Molecules

HC-030031

SKU : BHB21300168

A Selective TRPA1 Channel Blocker

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Alomone Labs

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Mfr.No.	H-105, H-105_10 mg, H-105_100 mg, H-105_25 mg, H-105_250 mg, H-105_50 mg
Description	HC-030031 (#H-105) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H21N5O3.
Background	HC-030031 is a selective small molecule that acts as a TRPA1 channel blocker. It was used to evaluate the role of TRPA1 receptors in models of inflammatory and neuropathic pain, and in tests of acute heat sensitivity and motor coordination1.Transient receptor potential ankyrin subfamily, member 1 (TRPA1) is a non-selective cation channel originally characterized as a noxious cold-activated ion channel. Several studies have showed that a large number of pungent and irritant compounds can activate TRPA1 channel. It has been suggested that TRPA1 may be involved in the normal detection of pain.HC-030031 has the ability to attenuate the mechanical hypersensitivity in rats 6 weeks post surgery and in other models of chronic inflammatory and neuropathic pain1,2.Intraperitoneal injection of HC-030031 was shown to inhibit AITC and formalin-evoked TRPA1 currents in vitro, and inhibit AITC and formalin-induced nociceptive behaviors in vivo1.Several studies have shown that HC-030031 interferes with glucose tolerance independently of TRPA13. It has an IC50 value of 4.9 uM1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	349085-38-7
Molecular Weight	355.4
Solubility	Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	TRPA1 channels
Source	Synthetic
Activity	HC-030031 has an IC50 of 5 uM for antagonizing formalin-evoked Ca2+ influx1. It blocks TRPA1 channels.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Eid, S.R. et al. (2008) Mol. Pain 4, 48. Sa?at, K. and Filipek, B. (2015) J. Zhejiang Univ. Sci. B 16,167. Andersson, D.A. et al. (2013) PLoS One 8, e77986. Eid, S.R. et al. (2008) Mol. Pain 4, 48.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300168-1	H-105_10 mg	10 mg	$50		Add to Cart
BHB21300168-2	H-105_100 mg	100 mg	$134		Add to Cart
BHB21300168-3	H-105_25 mg	25 mg	$66		Add to Cart
BHB21300168-4	H-105_250 mg	250 mg	$235		Add to Cart
BHB21300168-5	H-105_50 mg	50 mg	$85		Add to Cart

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