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Home / Primary Antibodies / IHC Antibodies

PARK2 Antibody

SKU : BHA10557130

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA017451KA01HU
Alternative Names	PARK2;AR-JP;LPRS2;PDJ;PRKN;Parkin
Categories	Primary Antibodies
Description	Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box. In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin.
Hgnc	28442
Host	Rabbit
Immunogen	Recombinant protein of Human PARK2
Intended Use	For research use only. Not for human, diagnostic or therapeutic use.
Involvement In Disease	Parkinson disease (PARK); Parkinson disease 2 (PARK2)
Isotype	IgG
Mgi	1914018
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Parkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box. In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin.
Size	100μl(100μg)
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm, cytosol, Nucleus, Endoplasmic reticulum, Mitochondrion

Antigen	PRKN
Rgd	1311045
Target Details	The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
Uniprot	O60260
Database Links	HGNC:8607 OMIM:168600 KEGG:hsa:5071 STRING:9606.ENSP00000355865 UniGene:Hs.132954
Function	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2
Pathway	Protein processing in endoplasmic reticulum Ubiquitin mediated proteolysis
Protein Families	RBR family, Parkin subfamily
Research Area	Apoptosis
Tissue Specificity	Highly expressed in the brain including the substantia nigra. Expressed in heart, testis and skeletal muscle. Expression is down-regulated or absent in tumor biopsies, and absent in the brain of PARK2 patients. Overexpression protects dopamine neurons fro

Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Format	liquid
Purification	Affinity purification
Purity	Affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:2000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;WB:1:500-1:2000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557130	CSB-PA017451KA01HU	100μl	$387.33		Add to Cart

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