MHC ClassII(I-A/I-E)-KO(NMG)

Mfr.No.	NM-NSG-003
Description	All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1,H2-Aa,H2-Eb1,H2-Eb2,H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins. H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, H1-Ea-ps NCBI ID: 14961, 14960, 14969, 381091, 100504404 MGI ID: 103070, 95895, 95901, 95902, 95900 Ensembl ID: ENSMUSG00000073421,ENSMUSG00000036594,ENSMUSG00000060586 ,ENSMUSG00000067341,ENSMUSG00000036322 Pubmed: H2-Ab1,H2-Aa,H2-Eb1,H2-Eb2,H1-Ea-ps Human Ortholog: HLA-DQB1,HLA-DQA1,HLA-DRB5,HLA-DRA
Nomenclature	NOD-Prkdc^scidIl2rg^em1H2-Ab1^em1H2-Aa^em1H2-Eb1^em1H2-Eb2^em1H2-Ea-ps ^em1Smoc
Strain	Developing
KI/KO Gene	H2-Ab1, H2-Aa, H2-Eb1, H2-Eb2, H1-Ea-ps
Synonyms	Abeta A beta H-2Ab H2-Ab Ia2 Ia-2 IAb I-Ab I-Abeta Rmcs1,Aalpha A alpha H-2Aa Ia1 Ia-1 I-Aalpha,H-2Eb Ia4 Ia-4,A130038H09Rik H-2Eb2 Ia5 Ia-5,H-2Ea Ia3 Ia-3 I-Ealpha

Research Application	Immunodeficient, Immunodeficiency, Immune System, Transplantation Research

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