R26-pAPOE-hCYP3A4(FVB)

Mfr.No.	NM-KI-18032
Description	This knock-in model was generated by inserting the human CYP3A4 cDNA driven by the liver-specific APOE promoter into the mouse Rosa26 site, which can be used to obtain liver-expressed CYP3A4 humanized model after mating with the Cyp3a13 gene and other Cyp3a family gene knockout mice. This model can be used with NM-KI-18033 mice which has gut-specific expression of human CYP3A4 to compare the contribution of intestinal versus hepatic metabolism to the biotransformation of a test article. NCBI ID: 14910 MGI ID: 104735 Ensembl ID: ENSMUSG00000086429 Pubmed: Gt(ROSA)26Sor Human Ortholog: On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Nomenclature	FVB-Gt(ROSA)26Sor^{em1(pAPOE-CYP3A4)Smoc}
Strain	Embryo cryopreservation
KI/KO Gene	Gt(ROSA)26Sor
Synonyms	R26,ROSA26,AV258896,Gtrgeo26,Gtrosa26,Thumpd3as1

Research Application	Metabolism, Humanized Drug Targets

Have you used this product?

SKU	Supplier No.	Your price	Quantity
BHAM02218	NM-KI-18032	-		Add to Quote