Rag1-KO(Rag1-EGFP)

Mfr.No.	NM-KI-00069
Description	A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model. NCBI ID: 19373 MGI ID: 97848 Ensembl ID: ENSMUSG00000061311 Pubmed: Rag1 Human Ortholog: RAG1
Nomenclature	B6;129S-Rag1^{tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc}
Strain	Repository Live
KI/KO Gene	Rag1
Synonyms	Rag-1

Research Application	Immunodeficient, Immunodeficiency, Tumor-Bearing Model

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