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Home / Primary Antibodies / Polyclonal Antibodies

MAVS antibody

SKU : BHA10810223

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Mfr.No.	FNab10248
Background	Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES(CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.It can undergoe phosphorylation on multiple sites and ubiquitination, which may together cause the molecular weight migrate to about 70 kDa despite the predicated 57 kDa.
Clonality	polyclonal
Host	Rabbit
Immunogen	mitochondrial antiviral signaling protein
Immunogen Region	mitochondrial antIVIral signaling protein
Isotype	IgG
Molecular Weight	40kDa,56kDa,70kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:500-1:2000;IHC: 1:50-1:500
Synonyms	CARD adapter inducing interferon beta,Interferon beta promoter stimulator protein 1,Cardif,Putative NF-kappa-B-activating protein 031N,Virus-induced-signaling adapter

Uniprot	Q7Z434
Gene Id	57506
Research Area	Immunology, Signal Transduction

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000;IHC: 1:50-1:500

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10248.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810223	FNab10248	100ug	$240		Add to Cart

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