Mouse Anti-Human Mitofusin 2 Monoclonal IgG2a

Mfr.No.	SMC-457, SMC-457D, SMC-457D-A390, SMC-457D-A488, SMC-457D-A594, SMC-457D-ALP, SMC-457D-APC, SMC-457D-BI, SMC-457D-FITC, SMC-457D-HRP, SMC-457D-PCP, SMC-457D-RPE, SMC-457S
Immunogen Species	Human
Alternative Names	CMT2A Antibody, CMT2A2 Antibody, CPRP 1 Antibody, CPRP1 Antibody, Fzo Antibody, HSG Antibody, hyperplasia suppressor gene Antibody, Hypertension related protein 1 Antibody, KIAA0214 Antibody, MARF Antibody, MFN 2 Antibody, Mfn2 Antibody, Mitochondrial assembly regulatory factor Antibody, Mitofusin-2 Antibody, Mitofusin2 Antibody, Transmembrane GTPase MFN2 Antibody
Antigen	Mitofusin 2
Categories	Antibodies
Cellular Localization	Mitochondrion, Mitochondrion Outer Membrane
Certificate Of Analysis	1 ug/ml of SMC-457 was sufficient for detection of Mitofusin-2 in 20 ug of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Alkaline Phosphatase, APC, Biotin, FITC, HRP, PerCP, RPE
Description	Mouse Anti-Human Mitofusin 2 Monoclonal IgG2a
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1., Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
Isotype	IgG2a
Launch Date	2013/10/29
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q80U63
Accession Number	NP_573464.2
Gene Id	170731
Target	Mitofusin 2
Clone No	S153-5
Research Area	Cell Signaling, Neurodegeneration, Cell Markers, Cancer, Apoptosis, Neuroscience

Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~90kDa. No cross-reactivity against Mitofusin-1.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11904590-1	SMC-457D	Unconjugated	100 ug	$330	Add to Cart
BHA11904590-2	SMC-457D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11904590-3	SMC-457D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11904590-4	SMC-457D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11904590-5	SMC-457D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11904590-6	SMC-457D-APC	APC	100 ug	$382	Add to Cart
BHA11904590-7	SMC-457D-BI	Biotin	100 ug	$378	Add to Cart
BHA11904590-8	SMC-457D-FITC	FITC	100 ug	$374	Add to Cart
BHA11904590-9	SMC-457D-HRP	HRP	100 ug	$370	Add to Cart
BHA11904590-10	SMC-457D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11904590-11	SMC-457D-RPE	RPE	100 ug	$380	Add to Cart
BHA11904590-12	SMC-457S	Unconjugated	12 ug	$44	Add to Cart

Mitofusin 2 Antibody, Clone S153-5 - SMC-457

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