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Home / Primary Antibodies / Polyclonal Antibodies

NFKBIE Antibody (CSB-PA953030)

SKU : BHA10549982

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA953030
Alternative Names	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Categories	Primary Antibodies
Description	The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.
Host	Rabbit
Immunogen	Fusion protein of Human NFKBIE
Isotype	IgG
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.
Species	Homo Sapiens (Human)
Subcellular Location	Cytoplasm

Antigen	NFKBIE
Uniprot	O00221
Database Links	HGNC:7799 OMIM:604548 KEGG:hsa:4794 STRING:9606.ENSP00000275015 UniGene:Hs.458276
Function	Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Pathway	B cell receptor signaling pathway T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Adipocytokine signaling pathway Neurotrophin signaling pathway
Protein Families	NF-kappa-B inhibitor family
Tissue Specificity	Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.

Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form	Liquid
Format	Liquid
Purification	Antigen affinity purification
Purity	Antigen affinity purification
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:50-1:200

Tested Application

ELISA,WB,IHC;ELISA:1:1000-1:2000,WB:1:200-1:1000,IHC:1:50-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10549982	CSB-PA953030	50ul	$166		Add to Cart
BHA10549982	CSB-PA953030	100ul	$299		Add to Cart

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