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Home / Biochemicals / Small Molecules

Picrotoxin

SKU : BHB21300282

An Antagonist of GABA(A), Glycine, and 5-HT3 Receptors

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Mfr.No.	P-325, P-325_1 g, P-325_10 g, P-325_5 g, P-325_500 mg
Description	Picrotoxin (#P-325) is a highly pure, natural, and biologically active compound.
Molecular Formula	C15H18O7·C15H16O6.
Synonyms	Natural
Background	Picrotoxin (PTX) is a plant-derived alkaloid that originally showed to be a noncompetitive antagonist of GABA(A) receptors. Later it was discovered that picrotoxin inhibits other anion-selective ligand-gated anion channels including glycine and 5-hydroxytryptamine type 3 (5-HT3) receptors. Inhibition by picrotoxin is likely in a noncompetitive, use-facilitated manner through binding to the channel pore of the receptor1,2.5-HT3 receptor is a member of the cys-loop superfamily of ligand-gated ion channels (LGICs) that includes nicotinic acetylcholine receptors, GABAA, glycine receptors, glutamate and purinergic receptors1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water to high-micromolar concentrations (50 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Cas Number	124-87-8
Molecular Weight	602.58
Solubility	Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).
Target	GABA(A), Glycine, 5-HT3 receptors
Activity	Picrotoxin, an equimolar mixture of picrotoxinin and picrotin, is a non-competitive antagonist of the GABA(A) receptors (IC50 = 2.4 uM - 17 uM)1, an antagonist of glycine receptors (IC50 = 2.7 uM - 6.4 uM)2 and of 5-HT3 receptors (IC50 = 41.2 uM)3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: (1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl--6,11-)tetradecane5,13.03,5.09,12trioxapentacyclo(6.4.1.1-,7,104dione;(1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-dione-6,11-)tetradecane5,13.03,5.09,12rioxapentacyclo(6.4.1.1t

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Wang, D.S. et al. (2006) J. Biol. Chem. 281, 3841. Das, P. and Dillon, G.H. (2005) J. Pharmacol. Exp. Ther. 314, 320. Dillon, G.H. et al. (1995) Br. J. Pharmacol. 115, 539. Wang, D.S. et al. (2006) J. Biol. Chem. 281, 3841. Das, P. and Dillon, G.H. (2005) J. Pharmacol. Exp. Ther. 314, 320.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300282-1	P-325_1 g	1 g	$57		Add to Cart
BHB21300282-2	P-325_10 g	10 g	$286		Add to Cart
BHB21300282-3	P-325_5 g	5 g	$203		Add to Cart
BHB21300282-4	P-325_500 mg	500 mg	$51		Add to Cart
BHB21300282-5	P-325_5 g	5 g	$210		Add to Cart

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