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Home / Primary Antibodies / Polyclonal Antibodies

Anti-alpha 1 Antitrypsin/SERPINA1 Antibody Picoband®

SKU : BHA21001002

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Mfr.No.	PB10097, PB10097-10ug, PB10097-Biotin, PB10097-Cy3, PB10097-Dylight488, PB10097-Dylight550, PB10097-Dylight594, PB10097-FITC, PB10097-HRP, PB10097-APC, PB10097-PE, PB10097-iFluor647, PB10097-carrier-free
Alternative Names	Alpha-1-antitrypsin
Background	SERPINA1 is also known as PI, A1A or AAT. This gene is mapped to 14q32.1. The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-alpha 1 Antitrypsin/SERPINA1 Antibody Picoband® catalog # PB10097. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in
Host	Rabbit
Immunogen Region	E. coli-derived human SERPINA1 recombinant protein (Position: E25-T204). Human SERPINA1 shares 72.8% amino acid (aa) sequence identity with rat SERPINA1.
Isotype	Rabbit IgG
Molecular Weight	52 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alpha-1-antitrypsin;Alpha-1 protease inhibitor;Alpha-1-antiproteinase;Serpin A1;Short peptide from AAT;SPAAT;SERPINA1;AAT, PI;PRO0684, PRO2209;
Tissue Specificity	Ubiquitous. Expressed in leukocytes and plasma. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P01009
Gene Id	5265
Gene Name	SERPINA1
Subcellular Location	Secreted. Endoplasmic reticulum. The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Western blot, 0.1-0.5ug/ml, Human, Rat<br>

Reference	1. Alpha 1-antitrypsin therapy mitigated ischemic stroke damage in rats.Moldthan HL, et al. J Stroke Cerebrovasc Dis, 2014 May-Jun.<br /><br />2. Mixture-based combinatorial libraries from small individual peptide libraries: a case study on 1-antitrypsin deficiency.Chang YP, et al. Molecules, 2014 May 16.<br /><br />3. Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer.Kwon CH, et al. Br J Cancer, 2014 Nov 11.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001002-1	PB10097	100 ug	-	$370		Add to Cart
BHA21001002-2	PB10097-10ug	10 ug	Sample	$99		Add to Cart
BHA21001002-3	PB10097-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001002-4	PB10097-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001002-5	PB10097-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001002-6	PB10097-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001002-7	PB10097-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001002-8	PB10097-FITC	100 ug	FITC	$570		Add to Cart
BHA21001002-9	PB10097-HRP	100 ug	HRP	$570		Add to Cart
BHA21001002-10	PB10097-APC	100 ug	APC	$670		Add to Cart
BHA21001002-11	PB10097-PE	100 ug	PE	$670		Add to Cart
BHA21001002-12	PB10097-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001002-13	PB10097-carrier-free	100 ug	carrier-free	$370		Add to Cart

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