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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cdk6 Antibody Picoband®

SKU : BHA21001768

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Mfr.No.	A00358, A00358-10ug, A00358-Biotin, A00358-Cy3, A00358-Dylight488, A00358-Dylight550, A00358-Dylight594, A00358-FITC, A00358-HRP, A00358-APC, A00358-PE, A00358-iFluor647, A00358-carrier-free
Alternative Names	cyclin-dependent kinase 6
Background	Cell division protein kinase 6, also called Plstire, is an enzyme that in humans is encoded by the CDK6 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. Radiation hybrid analysis and inclusion within a mapped clone place the CDK6 gene at 7q21. Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation and promotes G1/S transition. This gene also involved in initiation and maintenance of cell cycle exit during cell differentiation. It prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types. In addition, CDK6 plays a role in promoting the proliferation of beta-cells in pancreatic islets of Langerhans.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Cdk6 Antibody Picoband® catalog # A00358. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the en
Host	Rabbit
Immunogen Region	E. coli-derived human Cdk6 recombinant protein (Position: M1-A326).
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; CDK6; CDKN6
Tissue Specificity	Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q00534
Gene Id	1021
Gene Name	CDK6
Subcellular Location	Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Western blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Lena, A. M., Mancini, M., Rivetti di Val Cervo, P. R., Saintigny, G., Mahe, C., Melino, G., Candi, E. MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem. Biophys. Res. Commun. 423: 509-514, 2012.<br /><br />2. Lien, H.-C., Lin, C.-W., Huang, P.-H., Chang, M.-L., Hsu, S.-M. Expression of cyclin-dependent kinase 6 (cdk6) and frequent loss of CD44 in nasal-nasopharyngeal NK/T-cell lymphomas: comparison with CD56-negative peripheral T-cell lymphomas. Lab. Invest. 80: 893-900, 2000.<br /><br />3. Malumbres, M., Sotillo, R., Santamaria, D., Galan, J., Cerezo, A., Ortega, S., Dubus, P., Barbacid, M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118: 493-504, 2004. <br /><br />4. Veiga-Fernandes, H., Rocha, B. High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division. Nature Immun. 5: 31-37, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001768-1	A00358	100 ug	-	$370		Add to Cart
BHA21001768-2	A00358-10ug	10 ug	Sample	$99		Add to Cart
BHA21001768-3	A00358-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001768-4	A00358-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001768-5	A00358-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001768-6	A00358-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001768-7	A00358-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001768-8	A00358-FITC	100 ug	FITC	$570		Add to Cart
BHA21001768-9	A00358-HRP	100 ug	HRP	$570		Add to Cart
BHA21001768-10	A00358-APC	100 ug	APC	$670		Add to Cart
BHA21001768-11	A00358-PE	100 ug	PE	$670		Add to Cart
BHA21001768-12	A00358-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001768-13	A00358-carrier-free	100 ug	carrier-free	$370		Add to Cart

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