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Home / Primary Antibodies / Polyclonal Antibodies

Anti-DPYD Antibody Picoband®

SKU : BHA21001558

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Mfr.No.	A01749, A01749-10ug, A01749-Biotin, A01749-Cy3, A01749-Dylight488, A01749-Dylight550, A01749-Dylight594, A01749-FITC, A01749-HRP, A01749-APC, A01749-PE, A01749-iFluor647, A01749-carrier-free
Alternative Names	dihydropyrimidine dehydrogenase
Background	DPYD (Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-DPYD Antibody Picoband® catalog # A01749. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Host	Rabbit
Immunogen Region	E. coli-derived human DPYD recombinant protein (Position: A356-Y511).
Isotype	Rabbit IgG
Molecular Weight	111 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Dihydropyrimidine dehydrogenase (NADP (+)); DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPYD
Tissue Specificity	Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q12882
Gene Id	1806
Gene Name	DPYD
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, WB
Description	Western blot, 0.1-0.5ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Albin, N., Johnson, M. R., Shahinian, H., Wang, K., Diasio, R. B. Initial characterization of the molecular defect in human dihydropyrimidine dehydrogenase deficiency. Proc. Am. Assoc. Cancer Res. (Abstract) 36: 211 only, 1995.<br /><br />2. McLeod, H. L., Collie-Duguid, E. S. R., Vreken, P., Johnson, M. R., Wei, X., Sapone, A., Diasio, R. B., Fernandez-Salguero, P., van Kuilenberg, A. B. P., van Gennip, A. H., Gonzales, F. J. Nomenclature for human DPYD alleles. Pharmacogenetics 8: 455-459, 1998.<br /><br />3. Ridge, S. A., Brown, O., McMurrough, J., Fernandez-Salguero, P., Evans, W. E., Gonzalez, F. J., McLeod, H. L. Mutations at codon 974 of theDPYD gene are a rare event. Brit. J. Cancer 75: 178-179, 1997.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001558-1	A01749	100 ug	-	$370		Add to Cart
BHA21001558-2	A01749-10ug	10 ug	Sample	$99		Add to Cart
BHA21001558-3	A01749-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001558-4	A01749-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001558-5	A01749-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001558-6	A01749-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001558-7	A01749-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001558-8	A01749-FITC	100 ug	FITC	$570		Add to Cart
BHA21001558-9	A01749-HRP	100 ug	HRP	$570		Add to Cart
BHA21001558-10	A01749-APC	100 ug	APC	$670		Add to Cart
BHA21001558-11	A01749-PE	100 ug	PE	$670		Add to Cart
BHA21001558-12	A01749-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001558-13	A01749-carrier-free	100 ug	carrier-free	$370		Add to Cart

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