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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Grancalcin/GCA Antibody Picoband®

SKU : BHA21002056

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Mfr.No.	A01237, A01237-10ug, A01237-Biotin, A01237-Cy3, A01237-Dylight488, A01237-Dylight550, A01237-Dylight594, A01237-FITC, A01237-HRP, A01237-APC, A01237-PE, A01237-iFluor647, A01237-carrier-free
Alternative Names	grancalcin
Background	Grancalcin is a protein that in humans is encoded by the GCA gene. This gene is mapped to 2q24.2. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Grancalcin/GCA Antibody Picoband® catalog # A01237. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
Host	Rabbit
Immunogen Region	E. coli-derived human Grancalcin/GCA recombinant protein (Position: A42-I217).
Isotype	Rabbit IgG
Molecular Weight	25 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Grancalcin; GCA; GCL
Tissue Specificity	Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P28676
Gene Id	25801
Gene Name	GCA
Subcellular Location	Cytoplasm. Cytoplasmic granule membrane. Peripheral membrane protein. Cytoplasmic side.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IF, IHC, ICC, WB, Flow Cytometry
Description	Western blot, 0.1-0.5ug/ml<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem. 267 (5): 292833.<br /><br />2. Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2): 54954. <br /><br />3. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2-3): 1514. <br /><br />4. "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002056-1	A01237	-	100 ug	$370		Add to Cart
BHA21002056-2	A01237-10ug	Sample	10 ug	$99		Add to Cart
BHA21002056-3	A01237-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002056-4	A01237-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002056-5	A01237-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002056-6	A01237-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002056-7	A01237-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002056-8	A01237-FITC	FITC	100 ug	$570		Add to Cart
BHA21002056-9	A01237-HRP	HRP	100 ug	$570		Add to Cart
BHA21002056-10	A01237-APC	APC	100 ug	$670		Add to Cart
BHA21002056-11	A01237-PE	PE	100 ug	$670		Add to Cart
BHA21002056-12	A01237-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002056-13	A01237-carrier-free	carrier-free	100 ug	$370		Add to Cart

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