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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HLA Class II DRB1/HLA-DRB1 Antibody Picoband®

SKU : BHA21002058

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Mfr.No.	A00568, A00568-10ug, A00568-Biotin, A00568-Cy3, A00568-Dylight488, A00568-Dylight550, A00568-Dylight594, A00568-FITC, A00568-HRP, A00568-APC, A00568-PE, A00568-iFluor647, A00568-carrier-free
Alternative Names	major histocompatibility complex, class II, DR beta 1
Background	HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. This gene is mapped to 6p21.32. DRB1 encodes the most prevalent beta subunit of HLA-DR. Several alleles of DRB1 (shared epitope alleles) are associated with an increased incidence of rheumatoid arthritis. HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. It plays a central role in the immune system by presenting peptides derived from extracellular proteins to T helper cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HLA Class II DRB1/HLA-DRB1 Antibody Picoband® catalog # A00568. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptide
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human HLA Class II DRB1/HLA-DRB1.
Isotype	Rabbit IgG
Molecular Weight	30 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	HLA class II histocompatibility antigen, DRB1-7 beta chain; MHC class II antigen DRB1*7; DR-7; DR7; HLA-DRB1
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P13761
Gene Id	3123
Gene Name	HLA-DRB1
Subcellular Location	Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane. Late endosome membrane. Trans-Golgi network membrane

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Western blot, 0.1-0.5ug/ml<br>

Reference	1. "Entrez Gene: HLA-DRB1 major histocompatibility complex, class II, DR beta 1".<br /><br />2. Gregersen PK, Silver J, Winchester RJ (Nov 1987). "The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis". Arthritis and Rheumatism.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002058-1	A00568	-	100 ug	$370		Add to Cart
BHA21002058-2	A00568-10ug	Sample	10 ug	$99		Add to Cart
BHA21002058-3	A00568-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002058-4	A00568-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002058-5	A00568-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002058-6	A00568-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002058-7	A00568-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002058-8	A00568-FITC	FITC	100 ug	$570		Add to Cart
BHA21002058-9	A00568-HRP	HRP	100 ug	$570		Add to Cart
BHA21002058-10	A00568-APC	APC	100 ug	$670		Add to Cart
BHA21002058-11	A00568-PE	PE	100 ug	$670		Add to Cart
BHA21002058-12	A00568-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002058-13	A00568-carrier-free	carrier-free	100 ug	$370		Add to Cart

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