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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Human RAB27A DyLight® 488 conjugated Antibody

SKU : BHA21001860

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Mfr.No.	A01608-Dyl488
Alternative Names	RAB27A, member RAS oncogene family
Background	Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene. The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Human RAB27A DyLight® 488 conjugated Antibody catalog # A01608-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Function	Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Host	Rabbit
Immunogen Region	E. coli-derived human RAB27A recombinant protein (Position: L98-K216).
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Specificity	No cross reactivity with other proteins.
Synonyms	Ras-related protein Rab-27A; Rab-27; GTP-binding protein Ram; RAB27A; RAB27
Tissue Specificity	Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Note	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Uniprot	P51159
Gene Id	5873
Gene Name	RAB27A
Subcellular Location	Membrane; Lipid-anchor. Melanosome.

Conjugates	DyLight 488

Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Form	Liquid
Storage	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications	Flow Cytometry
Description	Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells

Reference	1. Aksu, G., Kutukculer, N., Genel, F., Vergin, C., Omowaire, B. Griscelli syndrome without hemophagocytosis in an eleven-year-old girl: expanding the phenotypic spectrum ofRab27A mutations in humans. Am. J. Med. Genet. 116A: 329-333, 2003.<br /><br />2. Kuroda, T. S., Fukuda, M., Ariga, H., Mikoshiba, K. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. J. Biol. Chem. 277: 9212-9218, 2002.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001860-1	A01608-Dyl488	100 ug	-	$515		Add to Cart

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