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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PDCD4 Antibody Picoband®

SKU : BHA21001266

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Mfr.No.	A01105, A01105-10ug, A01105-Biotin, A01105-Cy3, A01105-Dylight488, A01105-Dylight550, A01105-Dylight594, A01105-FITC, A01105-HRP, A01105-APC, A01105-PE, A01105-iFluor647, A01105-carrier-free
Alternative Names	Programmed cell death protein 4
Background	Programmed cell death protein 4 (PDCD4) is a protein that in humans is encoded by the PDCD4 gene. It is mapped to 10q25.2. This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. It also encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PDCD4 Antibody Picoband® catalog # A01105. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of
Host	Rabbit
Immunogen Region	E. coli-derived human PDCD4 recombinant protein (Position: E346-L446). Human PDCD4 shares 97% and 96% amino acid (aa) sequence identity with mouse and rat PDCD4, respectively.
Isotype	Rabbit IgG
Molecular Weight	60 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Programmed cell death protein 4;Neoplastic transformation inhibitor protein;Nuclear antigen H731-like;Protein 197/15a;PDCD4;H731;
Tissue Specificity	Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q53EL6
Gene Id	27250
Gene Name	PDCD4
Subcellular Location	Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, WB
Description	Western blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Azzoni, L; Zatsepina, O; Abebe, B; Bennett, IM; Kanakaraj, P; Perussia, B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of immunology 161 (7): 3493500. <br /><br />2. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 61721.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001266-1	A01105	100 ug	-	$370		Add to Cart
BHA21001266-2	A01105-10ug	10 ug	Sample	$99		Add to Cart
BHA21001266-3	A01105-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001266-4	A01105-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001266-5	A01105-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001266-6	A01105-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001266-7	A01105-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001266-8	A01105-FITC	100 ug	FITC	$570		Add to Cart
BHA21001266-9	A01105-HRP	100 ug	HRP	$570		Add to Cart
BHA21001266-10	A01105-APC	100 ug	APC	$670		Add to Cart
BHA21001266-11	A01105-PE	100 ug	PE	$670		Add to Cart
BHA21001266-12	A01105-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001266-13	A01105-carrier-free	100 ug	carrier-free	$370		Add to Cart

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