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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SCN4B Antibody Picoband®

SKU : BHA21002147

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Mfr.No.	A06453-1, A06453-1-10ug, A06453-1-Biotin, A06453-1-Cy3, A06453-1-Dylight488, A06453-1-Dylight550, A06453-1-Dylight594, A06453-1-FITC, A06453-1-HRP, A06453-1-APC, A06453-1-PE, A06453-1-iFluor647, A06453-1-carrier-free
Alternative Names	sodium voltage-gated channel beta subunit 4
Background	Sodium channel beta-subunit 4, also known as SCN4B or Nabeta4, is a protein that in humans is encoded by the SCN4B gene. The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SCN4B Antibody Picoband® catalog # A06453-1. Tested in Flow Cytometry, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibitio
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human SCN4B, which shares 72.7% amino acid (aa) sequence identity with both mouse and rat SCN4B.
Isotype	Rabbit IgG
Molecular Weight	28 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Sodium channel subunit beta-4; SCN4B
Tissue Specificity	Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q8IWT1
Gene Id	6330
Gene Name	SCN4B
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, IHC-F, ICC, WB
Description	Western blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human<br> Immunocytochemistry, 0.5-1ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Li, R.-G., Wang, Q., Xu, Y.-J., Zhang, M., Qu, X.-K., Liu, X., Fang, W.-Y., Yang, Y.-Q. Mutations of the SCN4B-encoded sodium channel beta-4 subunit in familial atrial fibrillation. Int. J. Molec. Med. 32: 144-150, 2013.<br /><br />2. Medeiros-Domingo, A., Kaku, T., Tester, D. J., Iturralde-Torres, P., Itty, A., Ye, B., Valdivia, C., Ueda, K., Canizales-Quinteros, S., Tusie-Luna, M. T., Makielski, J. C., Ackerman, M. J. SCN4B-encoded sodium channel beta-4 subunit in congenital long-QT syndrome. Circulation 116: 134-142, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002147-1	A06453-1	-	100 ug	$370		Add to Cart
BHA21002147-2	A06453-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002147-3	A06453-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002147-4	A06453-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002147-5	A06453-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002147-6	A06453-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002147-7	A06453-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002147-8	A06453-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002147-9	A06453-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002147-10	A06453-1-APC	APC	100 ug	$670		Add to Cart
BHA21002147-11	A06453-1-PE	PE	100 ug	$670		Add to Cart
BHA21002147-12	A06453-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002147-13	A06453-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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