lymphotoxin beta receptor (TNFR superfamily, member 3);LTBR;CD18;D12S370;LT-BETA-R;TNF-R-III;TNFCR;TNFR-RP;TNFR2-RP;TNFRSF3 ;
Categories
Primary Antibodies
Description
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Host
Rabbit
Immunogen
Human LTBR
Isotype
IgG
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Species
Homo Sapiens (Human)
Subcellular Location
Membrane, Single-pass type I membrane protein
Antigen
LTBR
Target Details
This protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Pathway
HIF-1 signaling pathway NF-kappa B signaling pathway