SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae);SUMO2;HSMT3;MGC117191;SMT3B;SMT3H2 ;
Categories
Primary Antibodies
Host
Rabbit
Immunogen
Human SUMO2
Isotype
IgG
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Species
Homo Sapiens (Human)
Subcellular Location
Nucleus, Nucleus, PML body
Antigen
SUMO2
Target Details
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451