UBN1, also named as Protein VT4, belongs to the ubinuclein family. UBN1 acts as a novel regulator of senescence. It is involved in the formation of senescence-associated heterochromatin foci(SAHF), which represses expression of proliferation-promoting genes. UBN1 binds to proliferation-promoting genes. It may be required for replication-independent chromatin assembly. The antibody is specific to UBN1.
Categories
Primary Antibodies
Cellular Localization
Cell Junction, Nucleus, Tight Junction
Clonality
polyclonal
Description
UBN1, also named as Protein VT4, belongs to the ubinuclein family. UBN1 acts as a novel regulator of senescence. It is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. UBN1 binds to proliferation-promoting genes. It may be required for replication-independent chromatin assembly. The antibody is specific to UBN1.
Host
Rabbit
Immunogen
ubinuclein 1
Isotype
IgG
Molecular Weight
121 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cell junction, Nucleus, Tight junction
Synonyms
UBN1, VT4, Protein VT4, ubinuclein 1, HIRA binding protein
Antigen
UBN1-Specific
Uniprot
Q9NPG3
Research Area
Metabolism
Weight
121kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)