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Anti-Human respiratory syncytial virus(RSV) Fusion glycoprotein/RSV-F Neutralizing Antibody

SKU : BHA10324331

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-V1272
Antigen	Fusion Glycoprotein/RSV-F
Background	Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. The G protein mediates attachment of the virus to cell surface receptors, while the F protein promotes fusion of the viral and cellular membranes, allowing entry of the virus ribonucleoprotein into the cell cytoplasm. The fusion (F) protein of RSV is synthesized as a nonfusogenic precursor protein (F), which during its migration to the cell surface is activated by cleavage into the disulfide-linked F1 and F2 subunits. This fusion is pH independent and occurs directly at the outer cell membrane, and the F2 subunit was identifed as the major determinant of RSV host cell specificity. The trimer of F1-F2 interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and induces the fusion between host cell and virion membranes. Notably, RSV fusion protein is unique in that it is able to interact directly with heparan sulfate and therefore is sufficient for virus infection. Furthermore, the fusion protein is also able to trigger p53-dependent apoptosis.
Conjugate	Unconjugated
Host	Rabbit
Immunogen	Recombinant RSV (A2) Fusion glycoprotein / RSV-F Protein (His Tag)
Isotype	IgG
Reactivity	RSV

Clone No	R338

Buffer	0.2 um filtered solution in PBS
Concentration	1mg/mL
Purification	Protein A Affinity
Storage	Store at -20?. Avoid freeze / thaw cycles.

Applications	Microneutralizaiton?ELISA
Dilution	ELISA 1:1000-1:10000

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10324331	E-AB-V1272	100?L	$200		Add to Cart
BHA10324331	E-AB-V1272	200?L	$300		Add to Cart
BHA10324331	E-AB-V1272	500?L	$465		Add to Cart

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