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Home / Primary Antibodies / Polyclonal Antibodies

Anti-KV1.1 (KCNA1) (extracellular)-ATTO Fluor-594 Antibody

SKU : BHA21301054

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Alomone Labs

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Mfr.No.	APC-161-AR, APC-161-AR_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	KV1.1 is a mammalian voltage-dependent K+ channel, homologous to the Drosophila Shaker K+ channel. KV1.1 was the first mammalian KV channel to be cloned from mouse brain.1 Eight Shaker-related genes exist in mammals constituting the KV1, subfamily of the large KV channel family of genes.2A functional KV1 channel is either a membrane spanning homotetramer or heterotetramer, which is composed of members of the same subfamily. In addition several auxiliary subunits and intracellular proteins might interact with the channel and affect its function. The structure of KV1.1 channel is similar to all KV channels and includes six membrane spanning helices creating a voltage sensor domain and a pore domain.2The channel is expressed in neurons and cardiac and skeletal muscle tissue as well as in the retina and pancreas.2 The functional channel is considered low voltage activated and shows very little inactivation. Therefore, this channel activity influences the membrane potential and excitability of neurons and muscle. Mutations in the coding of KV1.1 gene were discovered in Episodic Ataxia patients.3KV1.1 channels are sensitive to low doses of TEA (0.3 mM) and 4-AP (0.29 mM), the "classical" non-selective potassium channel blockers.Several venomous toxins from snakes, scorpions and sea anemones are potent blockers (affecting the channels in the nanomolar range) of KV1.1 channels. Among these, the most potent and selective are alpha-Dendrotoxin (0.4-4 nM) and delta-Dendrotoxin (0.03-1.8 nM), Dendrotoxin-K (0.03 nM), Agitoxin-2 (0.044 nM) and Hongotoxin-1 (0.031 nM).4
Clonality	Polyclonal
Description	Anti-KV1.1 (KCNA1) (extracellular) Antibody (#APC-161) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, indirect flow cytometry and live cell imaging applications. It has been designed to recognize KV1.1 from human, rat and mouse samples. Anti-KV1.1 (KCNA1) (extracellular)-ATTO Fluor-594 Antibody (#APC-161-AR) is directly labeled with an ATTO-594 fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-594 fluorescent label belongs to the class of Rhodamine dyes and can be used with fluorescent equipment typically optimized to detect Texas Red and Alexa-594. Anti-KV1.1 (KCNA1) (extracellular)-ATTO Fluor-594 Antibody is especially suited for experiments requiring simultaneous labeling of different markers.
Formulation	PBS pH7.4, 1% BSA with 0.05% sodium azide
Host	Rabbit
Immunogen Region	1st extracellular loop
Isotype	Rabbit IgG
Reactivity	Rat, Mouse
Reconstitution	50 ul double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Potassium voltage-gated channel subfamily A member 1
UNSPSC Code	41116161
Note	Homology: Mouse - identical; human - 13/14 amino acid residues identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC161 Specifictiy: KCNA1 Is Toxin: No Standard quality control of each lot: Western blot analysis (unlabeled antibody, #APC-161), and immunocytochemistry (labeled antibody). Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	P10499
Gene Id	24520
Target	Potassium voltage-gated channel subfamily A member 1
Sequence	(C)KDDKDFTGTIHRID, corresponding to amino acid residues 193-206 of rat KV1.1

Conjugates	ATTO-594. Maximum absorption 601 nm; Maximum fluorescence 627 nm. The fluorescence is excited most efficiently in the 580 - 615 nm range. This label belongs to the class of Rhodamine dyes and can be used with fluorescent equipment typically optimized to detect Texas Red and Alexa-594.

Concentration	1 mg/ml
Form	Lyophilized powder
Preservative	1% BSA, 0.05% NaN3
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IC, IF, IHC, LCI
Dilution	1:100

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301054-1	APC-161-AR_50 mcl	50 mcl	$797		Add to Cart

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