Anti-undefined Antibody CR2,1952 Unconjugated BHA10207849

Mfr.No.	1380-MSM2-P0
Alternative Names	CD21 ; Complement C3d receptor (C3DR) ; Complement Receptor type 2 (CR2) ; CVID7 ; EBV receptor ; EBV-R ; Epstein-Barr virus receptor ; EVBR ; SLEB9
Antigen	CD21
Categories	Primary Antibodies
Cellular Localization	Cell Surface
Chromosome Location	1q32
Clonality	monoclonal
Conjugate	Unconjugated
Description	Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) / CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Host	Mouse
Immunogen	Recombinant human CR2 (CD21) protein fragment (around aa 44-196) (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	WEHI-231 cells and Tonsil
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P20023
Gene Id	1380
Clone No	CR2, 1952
Symbol	CR2
Weight	140kDa

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	200μg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml
Storage	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Applications

IHC-F

Description

Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes,Optimal dilution for a specific application should be determined., IHC-F

Dilution

Immunohistology (Formalin-fixed)

1-2μg/ml for 30 min at RT