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Home / Primary Antibodies / Polyclonal Antibodies

PDGFR alpha Antibody - SPC-1184

BHA11916110
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+1 866.986.9598
Email
[email protected]
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Swissprot P16234
Accession Number NP_006197
Gene Id 5156
Target PDGFR alpha
Research Area Cardiovascular System, Angiogenesis, Cardiovascular Growth Factors, Atherosclerosis, Vascular Inflammation, Inflammatory Mediators, Cancer, Tumor Biomarkers, Oncoproteins, Growth Factor Receptors, Cell Signaling, Growth Factors, PDGF, Protein Phosphorylation, Tyrosine Kinases, Receptor Tyrosine Kinases
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Widely expressed. Detected in platelets, brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue.
Scientific Background PDGFRA is a receptor-tyrosine kinase that is activated upon binding platelet-derived growth factor (PDGF). Ligand binding causes dimerization of the receptor to activate signalling cascades to activate effector substrates such as PIK3R1, PLCG1, and PTPN11. Effector substrates will cause release of calcium from endoplasmic reticulum, by PLCG1, and activation of AKT1, by PIK3R1. This ultimately leads to growth and proliferation in cells by the MAPK and STAT transcription factor activation. PDGFRA is negatively regulated by protein phosphatases to cause inactivation and internalization. Due to PDGFRA's role in cellular growth its dysfunction may lead tumourigenesis. A high number of gastrointestinal stromal tumours have been implicated in PDGFRA dysfunction and constitutive activation. Typically mis-sense or deletion mutations were found to cause constitutively activated PDGFRA. Furthermore, a fusion protein of PDGFRA with BCR can arise from a translocation event with the PDGFRA gene locus. This fusion protein has been implicated in the development of chronic myeloid leukemias.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 122.67 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11916110-1 SPC-1184D Unconjugated 100 ul $331
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BHA11916110-2 SPC-1184D-A390 ATTO 390 100 ul $385
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BHA11916110-3 SPC-1184D-A488 ATTO 488 100 ul $384
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BHA11916110-4 SPC-1184D-A594 ATTO 594 100 ul $384
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BHA11916110-5 SPC-1184D-BI Biotin 100 ul $380
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BHA11916110-6 SPC-1184D-FITC FITC 100 ul $375
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