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Home / Primary Antibodies / Monoclonal Antibodies

PSD 95 Antibody, Clone 6G6 - SMC-122

BHA11900320
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+1 866.986.9598
Email
[email protected]
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Swissprot P31016
Accession Number NP_062567.1
Gene Id 29495
Target PSD95
Clone No 6G6
Research Area Cell Markers, Neuron Markers, Postsynaptic Markers, Cell Signaling, Organelle Markers, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:250), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4).
PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~100kDa. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at ~75kDa and 50kDa in rat and mouse samples.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, IHC, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; AM
Dilution WB (1:250), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Chetkovich D.M., Bunn R.C., Kuo S.H., Kawasaki Y., Kohwi M., and Bredt D.S. (2002) J Neurosci. 22(15): 6415-25.

2. Cao J., Viholainen J.I., Dart C., Warwick H.K., Levland M.L. and Courtney M.J. (2005) J Cell Biol. 168(1): 117-26.

3. Kennedy M. (1997) Trends in Neurosci. 6: 264-268.

4. Irie M. et al. (1997) Science 277(5331): 1511-5.

5. Cai C. et al. (2006) J Biol Chem. 281: 4267-73.

6. Yao W.D. et al. (2004) Neuron 41: 625-38.

7. Cline H. (2005) Curr Biol. 15: R203-5.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11900320-1 SMC-122D Unconjugated 100 ug $306
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BHA11900320-2 SMC-122C Unconjugated 25 ug $145
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BHA11900320-3 SMC-122D-A390 ATTO 390 100 ug $360
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BHA11900320-4 SMC-122D-A488 ATTO 488 100 ug $359
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BHA11900320-5 SMC-122D-A594 ATTO 594 100 ug $359
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BHA11900320-6 SMC-122D-ALP Alkaline Phosphatase 100 ug $352
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BHA11900320-7 SMC-122D-APC APC 100 ug $358
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BHA11900320-8 SMC-122D-BI Biotin 100 ug $354
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BHA11900320-9 SMC-122D-FITC FITC 100 ug $350
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BHA11900320-10 SMC-122D-HRP HRP 100 ug $345
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BHA11900320-11 SMC-122D-PCP PerCP 100 ug $358
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BHA11900320-12 SMC-122D-RPE RPE 100 ug $355
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BHA11900320-13 SMC-122S Unconjugated 12 ug $44
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