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Home / Primary Antibodies / Polyclonal Antibodies

THEM4 Antibody (CSB-PA023494GA01HU)

BHA10548785
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Tel
+1 866.986.9598
Email
[email protected]
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Antigen THEM4
Rgd 1304723
Target Details Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. This protein negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.
Uniprot Q5T1C6
Database Links

HGNC:17947

OMIM:606388

KEGG:hsa:117145

STRING:9606.ENSP00000357804

UniGene:Hs.164070
Function Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed
Pathway PI3K-Akt signaling pathway
Protein Families THEM4/THEM5 thioesterase family
Tissue Specificity Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
Format Liquid
Purification Antigen Affinity purified
Purity Antigen Affinity purified
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Applications ELISA, WB, IHC, IF
Description ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF
Tested Application ELISA,WB,IHC,IF
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
SKU Supplier No. Size Your price Quantity
BHA10548785 CSB-PA023494GA01HU 100ul $600
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