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Home / Primary Antibodies / Polyclonal Antibodies

VP35 Antibody, HRP conjugated (CSB-PA856262LB01RCT)

SKU : BHA10515432

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA856262LB01RCT
Alternative Names	Polymerase cofactor VP35, VP35
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
Host	Rabbit
Immunogen	Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)
Isotype	IgG
Raised In	Rabbit
Reactivity	Reston Ebolavirus
Regulatory	RUO
Relevance	Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
Species	Reston Ebolavirus (Strain Philippines-96) (Rebov) (Reston Ebola Virus)
Subcellular Location	Virion, Host cytoplasm

Antigen	VP35
Uniprot	Q91DE0
Function	Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
Protein Families	Filoviridae polymerase cofactor VP35 family
Research Area	Others

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Format	Liquid
Purification	>95%, Protein G purified
Purity	>95%,Protein G purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Applications	ELISA
Description	ELISA
Tested Application	ELISA

Datasheet
ELISA Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10515432	CSB-PA856262LB01RCT	50ug	$166		Add to Cart
BHA10515432	CSB-PA856262LB01RCT	100ug	$299		Add to Cart

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