Flavopiridol-Resistant MCF-7 Cell Line (FLV1000)

Mfr.No.	T8035
Description	These cell lines were developed using MCF-7, a human breast cancer cell line expressing estrogren, progesterone and glucocorticoid receptors. Flavopiridol is a cdk inhibitor used in human clinial trials, however, the cellular resistance mechanisms are not yet understood. This MCF-7 sub-cell line (FLV1000) is resistant to 1000 nM flavopiridol. Cells were selected during MF-7 cell exposure to increasing flavopiridol concentrations. ABCG2 expression expression levels were analyzed through northern analysis revealing high levels. Additionally, immunoblot analysis confimed ABCG2 protein presences in the FLV1000 cell line. The cell lines are suitable for drug discovery related research.
Density	Recommended split ratio 1:10
Growth Properties	Adherent
Quantity	1x10⁶ cells / 1.0 ml
Organism	Human (H. sapiens)
Source Organ	Breast

Shipping	Dry Ice
Storage	-180°C

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SKU	Supplier No.	Your price	Quantity
BHC10901742	T8035	-		Add to Quote