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Home / Primary Antibodies / IHC Antibodies

Anti-SP4/SP3 Antibody BHA11301115

SKU : BHA11301115

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Mfr.No.	BS2030
Alternative Names	Transcription factor Sp3 ; SPR-2 ; SPR2 ; SP3 ; Transcription factor Sp4 ; SPR-1 ; SPR1 ; SP4
Antigen	SP4/SP3
Categories	Primary Antibodies
Clonality	polyclonal
Description	The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4(SPR-1). Sp transcription factors share similar structures but do not share similar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3,but not Sp2 or Sp4, interact with E2, a regulatory element for the β4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 mediated transcription.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 630-680 of Human Sp3.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q02447/Q02446
Uniprot	Q02447/Q02446
Weight	85 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: Sp3/4 (G659) polyclonal antibody detects endogenous levels of Sp3 and Sp4 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301115	BS2030	50µl	$190.44		Add to Cart
BHA11301115	BS2030	100µl	$294.44		Add to Cart

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