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Home / Proteins & Peptide / Proteins

IRL-1620

SKU : BHP21300116

A Selective and Potent Endothelin B Receptor Agonist

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Mfr.No.	SPE-220, SPE-220_10 mg, SPE-220_25 mg, SPE-220_5 mg
Description	A Selective and Potent Endothelin B Receptor Agonist
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. Avoid multiple freeze-thaw cycles to maintain biological activity. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%0.5% DMSO (v/v) is considered safe. For other experiments, a 5% DMSO (v/v) concentration is recommended.
Molecular Formula	C86H117N17O27
Background	IRL-1620 is a synthetic peptide that acts as a selective and potent ET-B (endothelin B) receptor agonist, a receptor belonging to the G-protein coupled receptors (GPCR) superfamily. IRL-1620 is a C-terminal linear peptide analog of endothelin (ET-1) with a structure that is based on the carboxy-terminal end of ET-1. IRL-1620 has the ability to produce vasodilation or vasoconstriction1.Endothelin 1 (ET-1) and its receptor ET-B play an important role in regulating renal function and blood pressure. ET-B receptor and ET-1 are both expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia2.Studies have shown that acute administration of an ET-B receptor agonist into the rat renal medulla leads to natriuresis and diuresis via a mechanism that is NOS1-dependent3.
Biological Activity	IRL-1620 is a selective and potent ET-B receptor agonist1,2.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1820 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%0.5% DMSO (v/v) is considered safe. For other experiments, a 5% DMSO (v/v) concentration is recommended.
Source	Synthetic peptide
Concentration	1 pM - 100 nM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: No
Cas Number	142569-99-1
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Asp1 = Suc-Asp.

Synonyms	Suc-(Glu9, Ala11,15) Endothelin-1, (8-21)
Gene Id	EDNRB
Sequence	DEEAVYFAHLDIIW-OH
Target	ET-B receptor

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day.

Applications	Aequorin functional assay, Calcium imaging assay

Reference	Mazzoni, M.R. et al. (1999) Br. J. of Phrmacol. 127, 1406. Bell, K.M. et al. (1999) Int. J. Cancer 80, 295. Xie, C. and Wang, D.H. (2009) Hypertension 54, 1298. Davenport, A.P. et al. (2016) Pharmacol. Rev. 68, 357. Takai, M. et al. (1992) Biochem. Biophys. Res. Commun. 184, 953.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300116-1	SPE-220_10 mg	10 mg	$184		Add to Cart
BHP21300116-2	SPE-220_25 mg	25 mg	$417		Add to Cart
BHP21300116-3	SPE-220_5 mg	5 mg	$117		Add to Cart

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