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Home / Proteins & Peptide / Proteins

alpha-Conotoxin MrIC

SKU : BHP21300161

An Antagonist and Partial Agonist of alpha7 nAChR

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Mfr.No.	STC-320, STC-320_0.5 mg, STC-320_1 mg, STC-320_10 mg, STC-320_5 mg
Description	An Antagonist and Partial Agonist of alpha7 nAChR
Reconstitution	Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Molecular Formula	C74H111N23O24S4
Background	alpha-Conotoxin MrIC is peptide toxin originally isolated from Conus marmoreus. It is a competitive and selective antagonist of alpha7 nicotinic acetylcholine receptor (nAChRalpha7). Peptide toxins belonging to alpha-conotoxin family are relatively short peptides, between 12?19 amino acid residues and demonstrate high affinity towards nAChRs. They are stabilized by two disulfide bonds1,2.In Ca2+ responses assay to alpha-Conotoxin MrIC in SH-SY5Y cells endogenously expressing alpha7 nAChR, alpha-Conotoxin MrIC elicits concentration-dependent increases in intracellular Ca2+ in the presence of the alpha7 nAChR-specific positive allosteric modulator PNU120596 with an EC50 value of 1.9 uM2. Interestingly, alpha-Conotoxin MrIC antagonizes nAChRalpha7 heterologously expressed in Xenopus oocytes1.nAChRs receptors are responsible for mediating the effects of the neurotransmitter acetylcholine (ACh). They play critical physiologic roles in the central and peripheral nervous system where they regulate neurotransmitter release, cell excitability, neuronal integration, and are involved in functions such as sleep and arousal patterns, fatigue, hunger, anxiety, and pain processing3,4.
Biological Activity	alpha-Conotoxin MrIC is a selective antagonist of alpha7 nAChR heterologously expressed in Xenopus oocytes, while acting as an agonist of endogenous alpha7 nAChR in the prescence of PNU-1205961.
Formulation	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Molecular Weight	1835 Da
Solubility	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Source	Synthetic peptide
Accession Number	F5C3U4
Concentration	1 - 10 uM
Form	Lyophilized
Notes	Bioassay Tested: yes Steril endotoxin free: no Is Toxin: Yes
UNSPSC Code	12352202
Lead Time	1-2 Business Days
Modifications	Disulfide bonds between: Cys3-Cys9 and Cys4-Cys17 Cys17 - C-terminal amidation
Origin	Conus marmoreus (Marble cone)

Synonyms	Mr1.7c
Gene Id	CHRNA7
Sequence	PECCTHPACHVSNPELC-NH2
Target	alpha7 nAChR

Country Of Origin	Israel/IL
Purity	>=98% (HPLC)
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage Before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Applications	Electrophysiology

Reference	Jin, A.H. et al. (2014) Biochemistry 53, 1. Mueller, A. et al. (2015) Biochem. Pharmacol. 94, 155. Lustig, L.R. (2006) Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 288, 424. McIntosh, J.M. et al. (2009) Biochem. Pharmacol. 78, 693. Jin, A.H. et al. (2014) Biochemistry 53, 1.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP21300161-1	STC-320_0.5 mg	0.5 mg	$235		Add to Cart
BHP21300161-2	STC-320_1 mg	1 mg	$333		Add to Cart
BHP21300161-3	STC-320_10 mg	10 mg	$1610		Add to Cart
BHP21300161-4	STC-320_5 mg	5 mg	$1153		Add to Cart

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