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Home / Proteins & Peptide

Human Recombinant Transthyretin Y78F Variant Protein Monomers BHP11901157

SKU : BHP11901157

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StressMarq Biosciences Inc.

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Mfr.No.	SPR-452, SPR-452B, SPR-452C, SPR-452E
Alternative Names	Amyloid polyneuropathy Protein Monomer, Amyloidosis I Protein Monomer, ATTR Protein Monomer, Carpal tunnel syndrome 1 Protein Monomer, CTS Protein Monomer, CTS1 Protein Monomer,= HEL111 Protein Monomer, HsT2651 Protein Monomer, PALB Protein Monomer, Prealbumin Protein Monomer, Prealbumin amyloidosis type I Protein Monomer, Prealbumin Thyroxine-binding Protein Monomer, TBPA Protein Monomer, Thyroxine binding prealbumin Protein Monomer, Transthyretin Protein Monomer, TTHY_HUMAN Protein Monomer,TTR Protein Monomer, TTR protein
Cellular Localization	Extracellular exosome, Cytoplasm, Extracellular Region, Lysosome
Certificate Of Analysis	Certified >95% pure using SDS-PAGE analysis.
Conjugate	No tag
Description	Human Recombinant Transthyretin Y78F Variant Protein Monomers
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For research use only.
Scientific Background	Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The mutant variant Y78F indicates a destabilization of the contacts between the alpha-helix and AB loop and the body of the molecule, potentially leading to applications in immne therapy for FAP (7).
Species	Human
Accession Number	NP_000362.1
Concentration	Lot/batch specific. See included datasheet.
Purification	Ion-exchange Purified
Expression System	E. coli
Biological Activity Abreviation	Under Investigation
Cite This Product	Human Recombinant TTR Protein (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SPR-452E)
Mol Weight	15.887 kDa
Nature	Recombinant
Protein Length	Full length

Gross Weight (kg)	1.4
Launch Date	03-18-2019
Net Weight (g)	0.5
Swissprot	P02766
Gene Id	7276
Research Area	Tangles & Tau, Neurodegeneration, Alzheimer's Disease, Parkinson's Disease, Synuclein, Neuroscience
Target	Transthyretin

Country Of Origin	Canada
Stock Product	Y
Tarriff Code	3822.00.1090
Shipping Temperature	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.
Purity	>95%
Storage Buffer	PBS pH 7.4
Storage Temperature	-80°C

Applications	In vivo assay, In vitro assay, WB, SDS-PAGE

Reference	1. Nemoto, T. et al. (1997) J.Biol Chem. 272: 26179-26187. 2. Minami, Y, et al. (1991), J.Biol Chem. 266: 10099-10103. 3. Arlander SJH, et al. (2003) J Biol Chem. 278: 52572-52577. 4. Pearl H, et al. (2001) Adv Protein Chem. 59: 157-186. 5. Neckers L, et al. (2002) Trends Mol Med. 8: S55-S61. 6. Pratt W, Toft D. (2003) Exp Biol Med. 228: 111-133. 7. Pratt W, Toft D. (1997) Endocr Rev. 18: 306- 360. 8. Pratt WB. (1998) Proc Soc Exptl Biol Med. 217: 420- 434. 9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA. 91: 8324- 8328. 10. Nemoto, T. (1997) Biochem and Mol. Bio Intl. 42 (5): 881-889.

Product Manual	Datasheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHP11901157-1	SPR-452B	100 ug	$427		Add to Cart
BHP11901157-2	SPR-452C	2X100 ug	$682		Add to Cart
BHP11901157-3	SPR-452E	5X100 ug	$1386		Add to Cart

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