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Home / Proteins & Peptide

Recombinant Human Antiviral innate immune response receptor RIG-I(RIGI),partial

SKU : BHP10500478

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP006638HU
Alternative Names	DEAD box protein 58RIG-I-like receptor 1 ,RLR-1Retinoic acid-inducible gene 1 protein ,RIG-1Retinoic acid-inducible gene I protein ,RIG-I, DEAD box protein 58RIG-I-like receptor 1 ; RLR-1Retinoic acid-inducible gene 1 protein ; RIG-1Retinoic acid-inducible gene I protein ; RIG-I
Antigen	DDX58
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Innate immune receptor which acts as a Cytoplasmic domain sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including mbers of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-430aa
Mol Weight	53.3kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Singleton-Merten syndrome 2 (SGMRT2)
Subcellular Location	Cytoplasm, Cell projection, ruffle membrane, Cytoplasm, cytoskeleton, Cell junction, tight junction
Uniprot	O95786, O95786
Database Links	HGNC:19102 OMIM:609631 KEGG:hsa:23586 STRING:9606.ENSP00000369213 UniGene:Hs.190622
Function	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include
Pathway	NF-kappa B signaling pathway
Protein Families	Helicase family, RLR subfamily
Research Area	Immunology
Tissue Specificity	Present in vascular smooth cells (at protein level).
Weight	53.3kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500478	CSB-EP006638HU	1mg	$1812		Add to Cart
BHP10500478	CSB-EP006638HU	100ug	$419		Add to Cart
BHP10500478	CSB-EP006638HU	20ug	$224		Add to Cart

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