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Home / Proteins & Peptide

Recombinant Human Interleukin-17A/IL-17A Protein (Yeast, His Tag)(Active)

SKU : BHP10302844

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030924
Description	A DNA sequence encoding human IL17A (Q16552) (Gly24-Ala155) was expressed with a polyhistidine tag at the N-terminus.
Alternative Names	Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17
Reconstitution	Please refer to the printed manual for detailed information.
Background	IL17; also known as IL17a; is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation; differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes; macrophages; dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members; IL-17/IL-17A; IL-17B; IL-17C; IL-17D; IL-17E/IL-25; and IL-17F; which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2); as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis; psoriasis and multiple sclerosis.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Reactivity	Human
Tag	N-His
Formulation	Lyophilized from sterile PBS; pH 7.4
Host	Yeast
Accession Number	Q16552
Endotoxin Level	Please contact us for more information.
Bioactivity	Measured by its binding ability in a functional ELISA. 1.Immobilized human His-IL17A at 10ug/mL (100uL/well) can bind biotinylated human IL17Ra-His; the EC50 of biotinylated human IL17Ra-His is 0.03-0.2ug/mL.2.Measured by its ability to induce IL-6 secretion by HFF human foreskin fibroblast cells. The EC50 for this effect is typically 5-25 ng/ml.
Mol Weight	17.3 kDa
Mw(kda)	17.3 kDa

Sequence Info	Gly24-Ala155

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302844	PKSH030924	100ug	$564		Add to Cart

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