A DNA sequence encoding the human MESDC2 (NP_055969.1) (Ala 34-Lys 230) was fused with a signal peptide at the N-terminus and a polyhistidine tag at the C-terminus.
Alternative Names
BOCA;MESD
Reconstitution
Please refer to the printed manual for detailed information.
Background
LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61 and MESDC2, is a member of the MESD family. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity resides in the N- and C-terminal unstructured regions. MESDC2 acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.
Reactivity
Human
Tag
C-His
Formulation
Lyophilized from sterile PBS, pH 7.4
Host
HEK293 Cells
Accession Number
NP_055969.1
Endotoxin Level
< 1.0 EU per ug as determined by the LAL method.
Mol Weight
23.6 kDa
Mw(kda)
23.6 kDa
Sequence Info
Ala 34-Lys 230
Shipping
This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.