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Home / Proteins & Peptide

Recombinant Human PARK7/DJ-1 Protein (His Tag)

SKU : BHP10302821

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030826
Description	A DNA sequence encoding the human PARK7 (Q99497-1) (Met 1-Asp 189) was fused with a polyhistidine tag at the C-terminus.
Alternative Names	DJ-1;DJ1;HEL-S-67p
Reconstitution	Please refer to the printed manual for detailed information.
Background	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile 20mM Tris, 150mM NaCl, 3mM DTT, 5% glycerol, pH 8.0
Host	E.coli
Accession Number	Q99497-1
Endotoxin Level	Please contact us for more information.
Mol Weight	21.3 kDa
Mw(kda)	21.3 kDa

Sequence Info	Met 1-Asp 189

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302821	PKSH030826	100ug	$535		Add to Cart

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