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Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0(F),partial

SKU : BHP10505185

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP356041HPO
Antigen	F
Tag	N-terminal 6xHis-B2M-tagged
Description	During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis
Regulatory	RUO
Relevance	During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Fusion glycoprotein F0; Short name= Protein F; Cleaved into the following 2 chains: 1. Fusion glycoprotein F2; 2. Fusion glycoprotein F1
Expression Region	27-529aa
Mol Weight	69.9 kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Virion membrane, Single-pass type I membrane protein, Host cell membrane, Single-pass membrane protein
Uniprot	P03420, P03420
Function	During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2
Protein Families	Paramyxoviruses fusion glycoprotein family
Research Area	Others
Weight	69.9 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505185	CSB-EP356041HPO	1mg	$1812		Add to Cart
BHP10505185	CSB-EP356041HPO	100ug	$419		Add to Cart
BHP10505185	CSB-EP356041HPO	20ug	$224		Add to Cart

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