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Home / Proteins & Peptide

Recombinant Human STXBP1/UNC18A Protein (His & GST Tag)

SKU : BHP10302862

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031010
Description	A DNA sequence encoding the human STXBP1 isoform 1 (P61764-1) (Met 1-Ser 594) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Alternative Names	MUNC18-1;NSEC1;P67;RBSEC1;UNC18
Reconstitution	Please refer to the printed manual for detailed information.
Background	Syntaxin-binding protein 1, also known as N-Sec1, Protein unc-18 homolog 1, MUNC18-1 and STXBP1, is a peripheral membrane protein which belongs to the STXBP / unc-18 / SEC1 family. STXBP1 is an evolutionally conserved neuronal Sec1/Munc-18 (SM) protein that is essential in synaptic vesicle release in several species. It may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. STXBP1 is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. It can interact with syntaxins 1, 2, and 3 but not syntaxin 4. STXBP1 may also play a role in determining the specificity of intracellular fusion reactions. Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4). Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
Reactivity	Human
Tag	N-His & GST
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, 0.5mM PMSF, 10% gly, pH 8.0
Host	Baculovirus-Insect Cells
Accession Number	P61764-1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	95.4 kDa
Mw(kda)	95.4 kDa

Sequence Info	Met 1-Ser 594

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 85 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302862	PKSH031010	100ug	$855		Add to Cart

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