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Home / Proteins & Peptide

Recombinant Human TGM2/Transglutaminase 2 Protein (His Tag)

SKU : BHP10302914

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031259
Description	A DNA sequence encoding the human TGM2 (NP_004604.2) (Met 1-Ala 687) was expressed, with a polyhistidine tag at the N-terminus.
Alternative Names	G-ALPHA-h;GNAH;HEL-S-45;TG2;TGC
Reconstitution	Please refer to the printed manual for detailed information.
Background	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase which also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which catalyzes transamidation reactions or acts as a G-protein in intracellular signalling. As an enzyme which is responsible for the majority of transglutaminase (TG) activity in the brain, TGM2 is likely to play a modulatory role in nervous system development and has regulatory effect on neuronal cell death as well. Most importantly, numerous studies have presented data demonstrating that dysregulation of TGM2 may contribute to the pathogenesis of many neurodegenerative disorders, including Huntington's disease, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis as well as nervous system injuries.
Reactivity	Human
Tag	N-His
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, 2mM DTT, 10% glycerol, pH 8.0
Host	Baculovirus-Insect Cells
Accession Number	NP_004604.2
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	79.6 kDa
Mw(kda)	79.6 kDa

Sequence Info	Met 1-Ala 687

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302914	PKSH031259	100ug	$732		Add to Cart

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