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Home / Proteins & Peptide

Recombinant Human UBE2M/UBC12 Protein

SKU : BHP10302795

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030703
Description	A DNA sequence encoding the human UBE2M (P61081) (Met 1-Lys 183) was expressed and purified; with additional two amino acids (Gly & Pro) at the N-terminus.
Alternative Names	NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M; UBC12; UBE2M;
Reconstitution	Please refer to the printed manual for detailed information.
Background	UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation; ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction; and thereby the fate of the substrate; is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space; a highly sophisticated conjugation machinery has been developed. In a sequential manner; ubiquitin becomes activated by an ubiquitin-activating enzyme (E1); which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next; ubiquitin-loaded E2s are interacting with ubiquitin protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system; wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans.
Reactivity	Human
Formulation	Lyophilized from sterile PBS; 10% glycerol; 1mM DTT; pH 8.0
Host	E.coli
Accession Number	P61081
Endotoxin Level	Please contact us for more information.
Mol Weight	21 kDa
Mw(kda)	21 kDa

Sequence Info	Met 1-Lys 183

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302795	PKSH030703	100ug	$670		Add to Cart

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