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Home / Proteins & Peptide

Recombinant Human Ubiquitin fusion degradation protein 1 homolog(UFD1L)

SKU : BHP10503733

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP842166HU
Antigen	UFD1
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
Source	E.coli
Abbreviation	UFD1L
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Ubiquitin fusion degradation protein 1 homolog; Short name= UB fusion protein 1
Expression Region	1-307aa
Mol Weight	61.5kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus, Cytoplasm, cytosol
Uniprot	Q92890, Q92890
Database Links	HGNC:12520 OMIM:601754 KEGG:hsa:7353 STRING:9606.ENSP00000263202 UniGene:Hs.474213
Function	Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I
Pathway	Protein processing in endoplasmic reticulum
Protein Families	UFD1 family
Research Area	Cell Biology
Tissue Specificity	Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
Weight	61.477kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503733	CSB-EP842166HU	1mg	$1812		Add to Cart
BHP10503733	CSB-EP842166HU	100ug	$419		Add to Cart
BHP10503733	CSB-EP842166HU	20ug	$224		Add to Cart

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