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Home / Proteins & Peptide

Recombinant Mouse B7-H4/VTCN1 Protein (aa 29-256, Fc Tag)

SKU : BHP10301606

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040913
Description	A DNA sequence encoding the mature form of mouse B7H4 (Q7TSP5) (phe 29-Ser 256) was fused with the Fc region of human IgG1 at the C-terminus.
Alternative Names	Vtcn1 ; B7h4 ; B7s1 ; B7x ; BC032925
Background	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X/ VTCN1/ B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X/ VTCN1/ B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X/ VTCN1/ B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6/ interleukin-6 and IL10/ interleukin-10 and inhibited by CSF2/ GM-CSF and IL4/ interleukin-4 on antigen-presenting cells.
Tag	Fc tag
Regulatory	RUO
Host	Human Cells
Endotoxin Level	< 1.0 EU per μg of the protein as determined by the LAL method
Nature	Recombinant

Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer	Lyophilized from sterile PBS, pH 7.4
Description	Please refer to the printed manual for detailed information.
Purity	> 95 % as determined by SDS-PAGE
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10301606	PKSM040913	100ug	$732		Add to Cart

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